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KMID : 1037020220110020104
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Medical Lasers; Engineering, Basic Research, and Clinical Application
2022 Volume.11 No. 2 p.104 ~ p.109
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Comparison of the 660 nm and 532 nm wavelengths for photobiomodulation therapy on dermal wounds in mice
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Ryu Hyun-Seok
Woo Seung-Hoon
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Abstract
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Background and Objectives: The objective of this study was to compare the effects of photobiomodulation using the 660 nm diode and 532 nm diode-pumped solid-state (DPSS) lasers on dermal wound healing in mice.
Materials and Methods: The dermal wound was induced by a circular incision on the mice's back using a No. 15 surgical blade. The mice were treated with photobiomodulation at an energy density of 4 J/cm2 daily for 10 days before sacrifice. The macroscopic and histological observations of the wound were done on days 3, 7, and 10.
Results: The dermal wound area reduction rates in the diode laser, DPSS laser, and control groups were 34.2% ± 3.5%, 33.2% ± 2.4%, 24.0% ± 2.7% on the 3rd day, 72.2% ± 2.8%, 64.8% ± 3.5%, 42.8% ± 5.0% on the 7th day, and 87.2% ± 3.7%, 82.2% ± 7.9%, 71.4% ± 4.0% on the 10th day (p < 0.05), respectively. Histological analysis showed that the laser treatment improved granulation tissue formation, epithelialization, collagen deposition, and vascularization compared to the control.
Conclusion: Diode and DPSS lasers significantly improved dermal wound healing in mouse models. Further investigations are needed to confirm the mechanisms involved during photobiomodulation on dermal wound healing.
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KEYWORD
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Photobiomodulation therapy, Wound healing, Low-level light therapy
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